Ankita RainaDenisa Allertovaqualifyingsecond round First Published: August 22, 2019, 3:30 PM IST Get the best of News18 delivered to your inbox – subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, Telegram, TikTok and on YouTube, and stay in the know with what’s happening in the world around you – in real time. New York: India’s top women’s singles player Ankita Raina crashed out of the women’s singles US Open qualifying event after a hard-fought three-set loss to Czech Republic’s Denisa Allertova.The world No 194 went down 7-6(5), 4-6, 2-6 to her Czech rival in a match that lasted two hours and 17 minutes, on Wednesday night. Ankita won the first set in a tie-breaker but failed to keep her momentum as Allertova broke the Indian to take the second set comfortably.In the decider, Ankita was broken again as she conceded the match.Sumit Nagal is the only Indian left in the qualifiers. He is scheduled to play Peter Polansky of Canada in the second round of the qualifiers.
Get the best of News18 delivered to your inbox – subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, Telegram, TikTok and on YouTube, and stay in the know with what’s happening in the world around you – in real time. Lionel Messi scored his first hat-trick of the season in a 4-1 win over Celta Vigo at the Camp Nou on Saturday. After scoring his 34th hat-trick, Messi has equalled the record of Cristiano Ronaldo’s hat-trick in the Spanish league. Celebrations were at its peak after the Argentinian striker’s magnificent footwork helped the Spanish outfit retain their top spot on the league standings. La Liga decided to cherish Messi’s stunning performance by giving it a Bollywood touch.La Liga posted a picture of Messi showing thumbs up after netting his hat-trick. Along with the picture, La Liga opted for a famous dialogue from Bollywood actor Amitab Bachchan’s film Kalia. La Liga wrote, “Hum Jaha Pe Khade Hote Hai, Line Wahi Se Shuru Hoti Hain”.Praising Messi for his free kicks, Barca defender Sergio Busquets said, “We have a very big advantage, we have the best player in the world on our side who is also the best at taking free-kicks.””Little by little he has been improving at free kicks, he used to find them hard. Having him around gives us a real boost,” he added.Currently, Barcelona lead the La Liga standings with 25 points from 12 games, level with second-placed Real Madrid who eased to a 4-0 win at Eibar. amitabh bachchanargentinabarcelonabollywood First Published: November 12, 2019, 10:47 AM IST
athleticsdutee chandTIME Next 100 First Published: November 13, 2019, 10:29 PM IST Get the best of News18 delivered to your inbox – subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, Telegram, TikTok and on YouTube, and stay in the know with what’s happening in the world around you – in real time. New Delhi: India sprinter Dutee Chand has been named in the TIME 100 Next, an expansion of the TIME 100 list of the most influential persons in the world.The list, an initiative of TIME magazine, highlights 100 rising stars who are shaping the future of business, entertainment, sports, politics, health, science, activism etc. “I am delighted to receive this recognition from the TIME magazine. I believe in gender equality. I will continue to fight for the rights of young girls and women in sports as well as in the larger society,” Dutee said in a statement.Dutee had won two silver medals — 100m, 200m — at Jakarta Asian Games and had become the first Indian woman sprinter to win gold at the Universiade in Napoli, where she competed in 100m,She was invited by the IAAF to compete at the women’s 100m event at the Doha World Championships in September but could qualify for the semifinals, fading in the heats after clocking 11.48s.
Chandigarh, Sep 23 (PTI) The Haryana government has decided to exempt the Continental Wrestling Entertainment tournaments from entertainment tax, an official release said today.The event is scheduled to be held in Gurgaon and Panipat on October 8 and 11, respectively.Chief Minister Manohar Lal Khattar, has approved the proposal to exempt the sale of tickets for the tournaments from entertainment tax, the statement said.Fifteen international wrestlers of WWE Wrestling and 35 Indian wrestlers would participate in this event, which would serve the objects of the sports in respect of fun, recreation, relaxation, competition and socio-economic development, the added. PTI SUN AJR RG AJR
Shimla, Jul 20 (PTI) At least 80 percent of the state’s youth will get jobs in the upcoming private projects, Himachal Pradesh Chief Minister Jai Ram Thakur said today.The government will ensure at least 80 percent employment opportunities for Himachalis in the upcoming private power, industrial and tourism projects, Thakur said in a meeting of investment targets in tourism, multipurpose power projects and power and industries here.The chief minister further said that the state has immense power potential and if fully exploited, has the capacity to transform the state’s economy.Five hydro power projects with a total capacity of 594 MW would be completed by next year. Eleven other projects with total capacity of 307 MW would be completed within the next few years, Thakur said.While reviewing the investment targets achieved in industries department, the CM said electricity duty on existing industries was reduced from four to two percent in small scale industries and from ten percent to seven percent in case of medium scale industries. Thakur said several man-made and natural water bodies of the hill-state could be developed as a major tourist attraction and that possibilities should be explored to introduce water sports activities in the Chamera water reservoir.Similarly, Pong Dam could become a major attraction not only for bird-lovers but also for water sports enthusiasts. PTI DJI PTI RHL RHL
About the authorFreddie TaylorShare the loveHave your say Ex-Man City keeper Hart hails David Silva: He was tiny, slow and one-footed!by Freddie Taylor24 days agoSend to a friendShare the loveFormer Manchester City goalkeeper Joe Hart still marvels at the transformation of David Silva since he joined the club.Silva arrived in England in 2010 with a big reputation from his success with Valencia.However, Hart recalls the little midfielder appearing tiny, slow and extremely one footed in early training sessions.Silva has gone on to become one of City’s greatest ever players.The former City goalkeeper told the Kickback podcast: “The wizard came over, I had no idea who he was.”£25 million, tiny, slow, only left footed and didn’t even know his position.”He seemed like a lovely guy, didn’t really speak much English.”He didn’t take over straight away but his consistency and quality were through the roof.”Just an all-round amazing player – there isn’t one negative to him, other than he’s small.”
EdgbastonWorld Cup 2019: Edgbaston will play host to semi-final in the 2019 edition and will host a total of five games, including a high-profile meeting of England and India.advertisement India Today Web Desk BirminghamMay 27, 2019UPDATED: May 28, 2019 17:18 IST Edgbaston, Birmingham (Getty Images)Edgbaston was established in 1882 and is the home of Warwickshire County Cricket Club and just like the 1979, 1983 and 1999 editions, Edgbaston will play host to an ICC Cricket World Cup semi-final in the 2019 edition as well. Edgbaston will host a total of five games including a high-profile meeting of England and India.The last ICC Cricket World Cup semi-final hosted by the venue was at the 1999 edition, which was between Australia and South Africa. Arguably the greatest ever ODI, it was ‘the’ match in which Allan Donald and Lance Klusener, being the men at the crease, had a mix-up while taking a run anf that too when the scores were level. The result was that Australia progressed to the World Cup final and South Africa were braded the ‘chokers’.Opened:1882Capacity: 21,000Ends: City End, Pavilion EndLocation: Birmingham, EnglandICC Cricket World Cup 2019 matches -15:00 IST: NZ vs RSA, Match 2515:00 IST: NZ vs PAK, Match 3315:00 IST: Eng vs IND, Match 3815:00 IST: BAN vs IND, Match 4015:00 IST: TBC vs TBC, 2nd Semi-Final (2 v 3)STATS – ODITotal matches: 58Matches won batting first: 24Matches won bowling first: 27Average 1st Inns scores: 227Average 2nd Inns scores: 179Highest total recorded: 408/9 (50 Ov) by Eng vs NZLowest total recorded: 70/10 (25.2 Ov) by AUS vs EngHighest score chased: 280/4 (53.3 Ov) by AUS vs EngLowest score defended: 129/7 (20 Ov) by IND vs EngFor sports news, updates, live scores and cricket fixtures, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for Sports news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnita Jat Tags :Follow 2019 World CupFollow Edgbaston Cricket GroundFollow Allan Donald
Las Vegas, where heaven and hell meet at practically every minute of every day. Walk a few blocks in just about any direction from the Las Vegas strip and you’ll find any and every vice you could ever want—from buffets at disgustingly low prices to escorts to Britney Spears or Donny and Marie.For three days at the beginning of March, heaven outweighed hell, though, as the Universal Whisky Experience was in town at Encore at The Wynn for it’s sixth-annual event. Event, though, doesn’t truly begin to explain it.If you have the money to drop on the High-Roller Experience ($2500), the event is more like a life-changing experience (and if you’ve been before, it’s like a chance to reinvigorate from a year spent not carousing around Sin City while having unprecedented access to some of the world’s rarest whiskies.On night one, VIPs were brought around to try the Super Pours—whiskies so rare and so expensive that at first it might be hard to believe that you’re allowed to drink them. Not only were you able to try the likes of The John Walker, Brora 37 Year Old, Laphroaig 32 Year Old and Balblair 1983 Single Cask (which were all, in their own ways and as you can imagine, stunning examples of whisky craftsmanship), but for tasting was the holy grail of whisky—Gordon & Macphail’s Mortlach 75Year Old.Yes, seventy-five-year-old whisky. It is, for those wondering, the world’s oldest, and as a VIP, you got to drink it. Take a moment to think about that—not only have you spent five hours drinking scotch worth more, in total, than the GDP of most third world countries, but amidst all this, you get to taste the promised land. This was whisky created before World War II. It was made, with passion and care, before most people reading this were born. There are two words, and two words only to describe an experience like this.Holy shit.Trying to describe this single first-fill Sherry butt-cask scotch whisky is not easy. How do you even come close to finding the right words to explain such a transcendent experience? You can talk about the fact that it’s 44% ABV or that it’s retail price is more than most sedans at $30,650 and comes in a special crystal decanter and is accompanied by a number of high-quality accouterments. You can talk about the tasting notes for the whisky—how even after seventy-five years, the scotch is still beautiful and bright, how there are floral notes in a places you might not think, or how the finish is slightly spiced and leaves you with a slight warmth.You could talk about all of that, or you could simply remember that this whisky is, simply, old as hell, and that you may never get to do this again. You close your eyes and take it all in, let it wash over you in wonderful, scotchy waves.That wasn’t even the end of the night, however. Following the Super Pours session, VIPs were treated to a five-star meal at Tableau in addition to whisky speed dating, wherein brand managers and distillers alike showed off more of their wares while giving anyone a chance to chat about the greatness before them.Related: Teeling’s Single Grain Whiskey and Cocktail RecipeThe next day, leading up to the pièce de résistance, the Nth Whisky Tasting, event-goers could learn more about what they were drinking by participating in master classes, such as Midleton Irish Whiskey’s master class, where tasters were able to not only sample some of Ireland’s newest products, but were treated to a look at Ireland’s rise in popularity in the whiskey world. Not often do you have people so intimately tied to a brand coaching you through a tasting. Some of the people running these master classes have spent their lives working with these products, and it shows. The worst part, often, was waiting to actually taste the whiskies as they sat in front of you, calling to you with their delightful brogues.Then, finally, on the second night, the main event—the Nth Whisky Tasting. What made this tasting such a success was not just the sheer amount of amazing whiskies available, but the knowledge of the people pouring it. It isn’t often that you get the opportunity to speak to a distiller about his or her product in such a laid back yet entertaining atmosphere. Looking around, you could tell one thing: people were having fun. Laughter mixed with chatter mixed with the sound of toasts for most of the event. For those that had been at the events the previous evening, it was a great chance to get another taste of the liquid gold that had already passed between their lips. For those who had just arrived, there was a bevy of products and expressions to try, even including some bourbons, tequilas, and other spirits. For those that enjoy more than just whisky, Davidoff was on hand, providing top quality cigars.The Universal Whisky Experience, ounce for ounce, is the event you save your pennies for, because it’s the event that will give you a chance to rub elbows with the biggest names in scotch and give you bragging rights for life. The Absolute Best Rye Whiskey Brands for Under $50 William Grant and Sons Launches New Single Malt Whisky Brand The Manual Spirit Awards 2019: The Best Craft Liquor Made in America The Best Bottles of Whiskey You Can Buy For $20 or Less The Best American Liqueur Editors’ Recommendations
La Nouvelle-Écosse souligne la 32e Journée internationale de la Francophonie, aujourd’hui 20 mars, par la publication d’un plan d’action visant à attirer les immigrants francophones et à les inciter à rester dans la province. La Journée internationale de la Francophonie célèbre la langue française et la culture francophone. « Notre communauté acadienne et francophone est une composante essentielle de l’identité et du patrimoine de la Nouvelle-Écosse, affirme Lena Metlege Diab, ministre des Affaires acadiennes et de la Francophonie. En cette Journée internationale de la Francophonie, nous célébrons la langue française et la culture francophone, et nous soulignons les importantes contributions des francophones à notre province et à notre pays. » L’immigration joue un rôle important à l’appui de la communauté acadienne et francophone de la Nouvelle-Écosse. C’est pourquoi l’Office de l’immigration de la Nouvelle-Écosse et l’Office des affaires acadiennes et de la francophonie ont élaboré le Plan d’action pour l’immigration francophone. Ce plan présente l’orientation stratégique et les mesures visant à encourager l’immigration francophone. Avec ces mesures, on compte attirer les étrangers francophones en Nouvelle-Écosse et appuyer l’établissement et l’intégration des immigrants francophones par l’accès à des services et à des programmes. « Il est pertinent de lancer ce plan pendant la Journée internationale de la Francophonie, ajoute Mme Metlege Diab. Les immigrants veulent s’installer dans notre province, et l’établissement de nouveaux arrivants contribuera à la croissance de notre population, au renforcement de notre économie et à la revitalisation de nos collectivités, et ce, au profit de tous les gens de la Nouvelle-Écosse. » Des renseignements supplémentaires au sujet du Plan d’action pour l’immigration francophone se trouvent au https://acadien.novascotia.ca/sites/default/files/inline/documents/fr_immigration_action_plan_fr.pdf .
MONTREAL – “BlacKkKlansman” director Spike Lee says the rise of right-wing movements and anti-immigrant sentiment isn’t just an American problem.While Lee has nothing but scathing criticism for U.S. President Donald Trump — whom he refers to only as “Agent Orange” — he told a Montreal audience that the phenomenon is a global one.“The one thing I hope when people see this film is that they don’t make the mistake of (thinking) this rise of the right is just a specific thing that’s happening in the United States of America,” he said.“This is happening worldwide.”Lee, who dressed all in black and donned a baseball cap, encouraged people to reject such movements, which he said seek to use immigrants as scapegoats for society’s ills.“We have to be smarter as a people and not go for that old divide-and-conquer stuff,” he said as he held court at an Old Montreal hotel.Lee made the comments at the Montreal International Black Film Festival, where he held a wide-ranging discussion on filmmaking, politics and the recent box-office success of movies featuring black directors and stars.“BlacKkKlansman” stars John David Washington as Ron Stallworth, a real-life black police detective who infiltrated a Ku Klux Klan cell in Colorado in the 1970s with the help of a white partner.The film ends with footage from last year’s white supremacist rally in Charlottesville, Va. — which shows that the kind of racism depicted in the film is neither fictional nor in the past, Lee said.When he saw the footage from the “Unite the Right” rally that showed a car ramming into a crowd of protesters, fatally striking 32-year old Heather Heyer, Lee knew he had the ending to his film, he said.“If I could have the power to bring Heather Heyer back and lose the ending I would do it like that,” said Lee, adding that he first called Heyer’s mother to ask if he could include her.“She’s dead now, a martyr. And I think that’s what resonates with the audience, that this is not some Hollywood bullshit.”The film also features footage of Trump, whom Lee accuses of contributing to the rise of the radical right by refusing to immediately denounce the racism of the Charlottesville organizers.Despite his criticisms, Lee also struck some optimistic notes.He said the success of “BlacKkKlansman” and last year’s superhero hit “Black Panther” mean that studios can no longer argue that films with black cast members and directors won’t be successful with a wider audience.And while he’s discouraged by persistent racism and Trump’s policies, Lee said he’s heartened by grassroots movements to bring positive change.He’s hoping some of that change might come in the U.S. mid-term elections, which he said might be the most important “in the history of the United States.”The 61-year-old filmmaker, who was making his third appearance at the festival, expressed his fondness for Montreal, which he first visited more than 50 years ago on a family trip to the Expo 67 world fair.“Montreal has supported my films. I like Montreal, it’s very close to New York, so why wouldn’t I want to come? It’s a beautiful city,” he said.Lee was scheduled to hold a conference at the festival Wednesday night to discuss his filmmaking journey and offer advice to aspiring writers and directors.Note to readers: This is a corrected story. A previous version had the incorrect state marker for Charlottesville.
Adrian Grenier wants you to stop sucking – and save the oceans.The star has posted a video to his official Facebook page calling on fans to stop using plastic straws.“We use 500 MILLION straws everyday in the US,” says the star. “They end up in our ocean.“But we have the power to change this and clean up our ocean.”Adrian and the Lonely Whale Foundation need your help – find out more here.
“Sri Lanka experienced the greatest improvement in its overall peacefulness following the ending of its civil war. Bhutan showed robust gains to enter the top 20 for the first time mainly as tensions eased surrounding ethnic-Nepali refugees. The Philippines also showed a robust rise across a number of indicators,” the Institute for Economics and Peace said.The trend data also show a substantial gap in peacefulness between democracies and other government types. The end of the civil war saw Sri Lanka make the biggest rise in the latest Global Peace Index (GPI) released in London today.Sri Lanka leaped nearly 30 places to be ranked at number 103 out of 158 countries with a score of 2,145 on the index. Data on Sri LankaFlawed democracies perform substantially better than hybrid and authoritarian regimes which suggest that measures of government repression, such as the ‘Political Terror Scale’ and the ‘Level of Internally Organised Conflict’, are close predictors of peacefulness.“What comes across dramatically in this year’s results and the six year trends is a shift in global priorities. Nations have become externally more peaceful as they compete through economic, rather than military means. The results for Sub Saharan Africa as a whole are particularly striking – regional wars have waned as the African Union strives to develop economic and political integration.” said Steve Killelea, founder and Executive Chairman of the IEP.“Peacefulness has returned to approximately the levels seen in 2007, but while external measures of peacefulness have improved, there has been a rise in internal conflict. This is particularly noticeable in the rise in fatalities from terrorist acts which have more than trebled since 2003.” (Colombo Gazette) The Asia Pacific region’s overall score improved by the largest extent from last year and included three of the top five risers. The 2012 GPI is the sixth edition of the world’s leading measure of global peacefulness. Produced by the Institute for Economics and Peace, the GPI ranks 158 nations using 23 qualitative and quantitative indicators which gauge ongoing domestic and international conflict, safety and security in society and militarization.
New Zealand Foreign Affairs Minister Murray McCully is to discuss human rights concerns on Sri Lanka when he visits the country next week.The Otaga Daily Times reported that in Sri Lanka, McCully will meet the ministers of External Affairs and Economic Development. “This is a good opportunity to discuss Sri Lanka’s hosting of the Commonwealth Heads of Government Meeting in November, as well as prospects for our quarter-billion dollar dairy trade.”“I also intend to discuss progress towards reconciliation following the end of the civil war and human rights issues.” (Colombo Gazette)
Dissanayake said that the transfer of Police officers affects their families, including the education of their children. Law and Order Minister Sagala Ratnayake told Parliament today that Police transfers were being carried out in accordance to the existing policy.The Minister said that annual transfers are implemented to ensure Police officers are not based at just one location but are able to experience situations in most parts of the country. Ratnayake was responding to a question raised by Janatha Vimukthi Peramuna (JVP) leader Anura Kumara Dissanayake with regards to the transfer of Police officers from the Eastern Province. Ratnayake said that a new policy is being worked on with regards to Police transfers and he hopes the new Policy will address any shortcomings in the current policy. (Colombo Gazette)
A Toronto woman has been arrested after assaulting another woman on an HSR bus.Around 8 pm Thursday night a woman and her friends got on an HSR bus at the GO Station on Hunter Street in Hamilton. Another woman, who was drinking alcohol on the bus, began to threaten the woman and then spat on her, twice.The bus driver stopped the bus and the woman who was drinking, along with a man left, but then began banging on the windows of the bus.Hamilton Police arrested the 32 year-old woman and charged her with assault, disturbance, uttering threats and failure to comply with probation.She will appear in court today.
Freshman linebacker Raekwon McMillan goes for a tackle during a game against Kent State on Sept. 13 at Ohio Stadium. OSU won 66-0.Credit: Mark Batke / Photo editorWhile many coaches wouldn’t admit it, Ohio State’s Urban Meyer had no problem saying his team had a talent advantage over Kent State.“Obviously a little talent advantage, but we had to have a game like this,” Meyer said after his team’s 66-0 thrashing of the Golden Flashes on Saturday.When a team has the quick success the Buckeyes had at Ohio Stadium — they jumped out to a 21-0 first-quarter lead — it gives the coaching staff a chance to throw young but unproven talent into the fire early and often.OSU did just that against Kent State as 12 redshirt-freshmen and 11 true freshmen took the field for the Buckeyes. Of those 23 players, few reaped the benefits more than freshman linebacker Raekwon McMillan.“Every time I came off the field, I just got a little more confidence here and there,” McMillan said after the game. “And then toward the second quarter, I felt like I can really do this.”As McMillan said he feels ready to be on the field for OSU, his numbers might have proved that for him as he led the team with seven total tackles and a pair of sacks.Regardless of the numbers he put on the score sheet, OSU co-defensive coordinator and safeties coach Chris Ash said he wanted to save his opinion on McMillan’s performance until after the team sees footage from the game.“Just from watching in the press box, it looked like he did a good job,” Ash said after the game. “Until we watch the tape, I don’t know. But it looked like he was active and around the ball.”The first-year OSU assistant said McMillan is still learning the game, but added that he is “naturally gifted” and can bring another dimension to the Buckeyes’ defense.“He brings a lot of athletic ability (and) toughness,” Ash said. “He’s got some juice to him, things like that.”McMillan enrolled at OSU in January after receiving the high school Butkus Award as the nation’s top linebacker after his senior season at Liberty County High School in Hinesville, Ga. ESPN and Rivals rated him the No. 1 high school inside linebacker as a five-star prospect before he committed to Meyer and the Buckeyes.After arriving in Columbus, McMillan said he was immediately taken under the wing of senior linebacker Curtis Grant. The freshman said the support he has received from Grant has done a lot to facilitate his success on the field.“Knowing that I’ve got support from my big brother (Grant) and a guy who’s been starting here,” McMillan said. “Going in and him telling me that he’s got confidence in me, that I can do it, really gave me confidence.”While Grant won the starting job heading into the season, he was able to give McMillan the support he needed despite the fact they were — and still are — directly competing for playing time, Ash said.“That’s a testament to the program coach Meyer has, when an older player is going to take a younger player that could potentially take his job underneath his wing and help him develop and grow and learn what he needs to learn in order to get out there and play,” Ash said. “It’s a great testament to Curtis, that tells you what type of person he is.”While Grant might be his big brother on the team, junior linebacker Joshua Perry said all of the veterans were excited to see McMillan and other young players at the position contribute against the Golden Flashes.“When a guy like Raekwon makes a play, or (freshman linebacker Dante Booker) makes a play, I think we’re more excited than they are that they actually made the play,” Perry said. “Which is a really good thing.”OSU is set to have a bye week before taking on Cincinnati on Sept. 27 at Ohio Stadium. Kickoff is set for 6 p.m.
Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. Prof David Allsop, Professor of Neuroscience, University of Lancaster, said: “This study shows convincingly that it is possible to reduce the extent of amyloid plaque formation in the brains of people with very early signs of dementia.Encouragingly, this treatment also appeared to slow memory decline, demonstrating that amyloid formation is a direct or indirect cause of memory loss. This has been suspected for some time, but has never been proven in humans.“These findings could be a game changer if the effects on memory decline can be confirmed in more extensive follow-on studies.”The Alzheimer’s Society said the “most compelling” evidence from the trial was the fact that more amyloid was cleared when patients took higher doses of the drug.Dr James Pickett, head of research at the charity, said: “No existing treatments for Alzheimer’s directly interfere with the disease process, and so a drug that actually slows the progress of the disease by clearing amyloid would be a significant step.”While there were hints that it might have an effect on the symptoms of the disease, we need to see the results from further, larger research trials to understand whether this is the case. These larger trials are now under way, including in the UK, and due to finish in 2020.”Prof Richard Morris, Professor of Neuroscience at the University of Edinburgh, said: “We cannot yet say we have a cure for Alzheimer’s, as this is only a first step … but the importance of this first step cannot be understated.“Let’s keep our fingers crossed for success in the next steps.”To join a trial click here Scientists said they were amazed to find that patients treated with the highest dose of the antibody drug aducanumab experienced an almost complete clearance of the amyloid plaques that prevent brain cells communicating, leading to irreversible memory loss and cognitive decline.Crucially they also found that after six months of the treatment, patients stopped deteriorating compared with those taking a placebo, suggesting that their dementia had been halted. More than 800,000 people in Britain suffer from dementia, and the majority have Alzheimer’s diseaseCredit:Alamy The red marks show amyloid plaques but after a year they are gone in the highest dose group The drugs are given intravenously once a month Dr Alfred Sandrock, from the Massachusetts-based biotech company Biogen, which is hoping to bring the drug to market, said: “This is the best news that we have had in our 25 years and it brings new hope to patients with this disease.”There are currently 850,000 people living with dementia in Britain, a figure that is expected to rise to one million by 2025 and two million by 2050.The most common kind of dementia is Alzheimer’s disease, but scientists have been unable to reach consensus about the cause of the condition, and despite more than 400 drug trials, nothing has been shown to combat disease. The first drug that can prevent Alzheimer’s disease is finally on the horizon after scientists proved they can clear the sticky plaques from the brain which cause dementia and halt mental decline.Hailed as the “best news” in dementia research for 25 years, the breakthrough is said to be a potential “game changer” for people with Alzheimer’s. The last Alzheimer’s drug licensed in the UK became available more than a decade ago. Current treatments can reduce symptoms to some extent but doctors have nothing that can halt or slow progression of the disease.Not only does the new study suggest a treatment for the disease, but shows that the build-up of amyloid plaque in the brain is likely to be to blame.Aducanumab is a treatment made up of antibodies, tiny y-shaped proteins that latch on to dangerous substances in the body, acting like flags, showing the immune system what to clear away.Scientists tested various human immune cells with amyloid in a laboratory until they found one which produced an antibody that broke up the plaques. They then cloned it in large numbers for the new therapy, which is given intravenously just once a month. If shown to be effective in larger trials, the first drug to prevent dementia could be available in just a few years.”The results of this clinical study make us optimistic that we can potentially make a great step forward in treating Alzheimer’s disease,” said Prof Roger Nitsch, at the Institute for Regenerative Medicine at the University of Zurich.“In the high dose group the amyloid has almost completely disappeared. The effect size of this drug is unprecedented.“Despite it being a small sample there appeared to be a slowing of cognitive decline and functional decline. The group with a high degree of amyloid removal were basically stable. If we could reproduce this it would be terrific.” In the trial, which was reported in the journal Nature, scientists tested varying levels of the drug over a year, as well as giving one group a placebo. They found that more amyloid was removed as the dose increased. Brain scans of those given the highest dose shown virtually no amyloid left at all.The drug is likely to be most effective for patients in the very earliest stages of Alzheimer’s disease, or those who have not yet begun to show symptoms. Several universities are working on early blood tests for dementia which could pick the disease up a decade or more before the first physical signs appear.Dementia experts and charities said that the breakthrough offered real hope for the future treatment of Alzheimer’s disease. These findings could be a ‘game changer’ if the effects on memory decline can be confirmed in more extensive follow-on studiesDavid Allsop, Professor of Neuroscience, University of Lancaster There are now two large phase-three clinical studies taking place to further evaluate safety and efficacy on a total of 2,700 patients with early-stage Alzheimer’s disease and researchers are currently recruiting British participants.”These results provide tantalising evidence that a new class of drug to treat the disease may be on the horizon,” said Dr David Reynolds, chief scientific officer at Alzheimer’s Research UK.”The findings suggest that aducanumab may slow memory and thinking decline in people with early Alzheimer’s and, although the analysis is only exploratory in this early trial, it paints a positive picture for ongoing trials with the drug.”Although some people on the trial experienced side effects such as headaches, scientists believe that adjusting the dose may alleviate problems.
GARDAÍ IN CASTLEBLAYNEY are investigating a fatal road traffic collision in which a woman in her 50s was killed after being struck by a lorry.The incident happened on Main Street, Castleblayney at approximately 12.50pm this afternoon.The female pedestrian was pronounced dead at the scene and her body was removed to Our Lady of Lourdes Hospital, Drogheda.The driver of the lorry was uninjured.The Main Street is currently closed pending completion of an examination by Garda Forensic Collision Investigators and diversions are in place.Gardai wish to appeal for witnesses to contact Castleblayney Garda Station on 042-9747900, the Garda Confidential Telephone Line 1800 666 111 or any Garda Station.
IRELAND’S SYSTEM for electing members of the Dáil could face an unprecedented overhaul, following a decision by the Constitutional Convention today.A majority of the 100-member convention has said that electoral reform might include not only changes to the existing system of proportional representation, where members are elected by a single transferable vote, but also an entirely new electoral system.When asked what type of format they would like Irish elections to take, members heavily favoured the ‘mixed member’ system used in countries like Germany and New Zealand.Those systems ask voters to cast two separate votes: one for a constituency representative, and a separate vote for a specific political party. The final composition of the parliament is then influenced by the second vote, while the identities of the TDs themselves are governed by the first.This system was backed by 69 per cent of members, while a ‘proportional list system’ – where voters choose a party, and separately rank the party’s national candidates (or where the party itself ranks its candidates in order of preference) – was supported by 29 per cent of voters.Only 3 per cent of participants said they would favour a British-style ‘first past the post’ model, where the candidate with the highest number of first-preference votes wins a seat.A further investigation on the exact model that the Convention might recommend will be held next month.The Convention’s deliberations will also take into account the current system of multi-TD constituencies, whether ministers should remain members of the Oireachtas, the possibility of compulsory voting, and the overall size of the Dáil.Column: Seanad reform suggestions are practical but limit real bicameral changeRead: Constitutional Convention won’t discuss Seanad abolition
Laptops aimed at the small business market are an interesting juxtaposition of consumer and enterprise-class PCs, which more consumers should look at before deciding on the shiniest box at Best Buy.When product planners at the big PC companies plan their SMB-focused PCs, they literally take the best of the enterprise PCs and combine it with the most popular features found in consumer laptops. Things like anti-glare screens, spill-resistant keyboards, HDMI video, and colorful designs come together to make a PC that is a step above the usual consumer box, without much added price.Dell’s Vostro 3460 is one of these hybrids, utilizing a 14-inch chassis that doesn’t trade thinness & lightness for durability, but still measures 1.2-inches thin and under 5lbs with optical drive and 6-cell battery. You get an impressive four USB 3.0 ports, including one that will charge a mobile device. HDMI video output and a media card reader are standard, as are the business requisite VGA output and Ethernet ports.All of this is powered by a 3rd generation Intel Core i5 processor, giving you the latest Intel technology, and Windows 7 Professional 64-bit. Dell even includes 1 year of on-site service with the standard warranty, something you won’t ever see in a laptop from Best Buy.While the $649 price tag, marked down from $769, is already a competitive price for this system, what makes this deal extra hot is the added $100 Dell e-gift card. This bonus is good for anything on Dell.com and is perfect to accessorize your new PC or pick up some other choice electronics (Dell sells many mainstream tech items as well).Click here to get this deal from Dell.com. Total $120 instant savings applied automatically, $100 gift card delivered by email. This deal expires September 14 or sooner.